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In macrophages, the most pronounced reduction was around 20% for IL-1β (from above 300 to less than 250 pg/mL) and approximately 45% in TNF-α levels (from around 1800 to 1000 pg/mL) [30]

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In contrast, decreased levels of CD4 + CD25 high CD127 low T reg cells (44, 81) and reduced suppressive activity of T reg cells has also been found in PD patients (77)