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These findings collectively highlight therapeutic potential in targeting Warburg effect regulators through pharmacological or epigenetic approaches, with key glycolytic enzymes (HK2, PKM2, LDHA) representing strategic intervention points to disrupt both metabolic fueling and immunosuppressive mechanisms in CRC [21]

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CAR T cell products with a high content of T N , T CM , and T SCM cells display a superior antitumor response and in vivo persistence [37,38]