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Bañales-Luna, Figueroa-Vega, Marín-Aragón, and colleagues, publishing in Scientific Reports in 2020, reported associations between NNMT, FTO, and IRX3 genetic variants and both BMI and resting energy expenditure in a Mexican cohort — evidence that variation in the NNMT axis tracks with metabolic phenotype in humans, not only in mice

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But for some people, it persists