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Based on the metabolomics analysis we identified a total of 32 differential metabolites that were significantly reversed by TGP, and discovered 8 key metabolic pathways, including phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, histidine metabolism, starch and sucrose metabolism, arginine and proline metabolism, arginine biosynthesis, glutathione metabolism, and purine metabolism

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In microglial cultures, for instance, BDNF exerts activating effects while its sequestration inhibits microglial activation, motility, and production of tumor necrosis factor-α (TNF-α) [142]