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Theoretical and reported concerns Off-target cell death: no compound is perfectly selective, so healthy cells with temporarily high FOXO4 could be affected in theory

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Smirnoff’s research team discovered the novel and unique GDH enzyme in cell-free extracts from leaves of thale cress and Pisum sativum “pea” embryonic axes, which promotes the L-galactose-dependent reduction of NAD + (Wheeler et al., 1998)