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4 Lipid metabolism as a therapeutic target for MM 4.1 Current treatment modalities targeting lipid metabolism Statins, by inhibiting HMG - CoA reductase in the mevalonate pathway, block the biosynthesis of cholesterol and isoprenoid intermediates (78–85)

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Results ATX has protective effect on IS HE staining revealed that the MCAO group exhibited edema, structural vacuolization, nuclear condensation, and an increase in eosinophil counts in the ischemic penumbra tissue