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It means that long-term safety cannot be assumed from short or limited experiments

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This notion is illustrated by MASLD and MASH pathobiology [99] pointing to the investigation of copper’s role as a potential avenue to uncover important sex-specific pathogenic mechanisms of MASLD initiation, and fibrotic progression [49,58,79,100-102] and the development of targeted therapies that, moving beyond symptomatic treatment, address the underlying root causes of MASLD in individual patients [86]