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Mice that overexpress Jak2VF in their erythroid lineage (VFEpoR mice) exhibit heightened necrosis in atherosclerotic plaque and erythrocytic ferroptosis, and VFEpoR increases erythrocyte lipid hydroperoxide and decreases antioxidant defense ability
Anti-Oxidant
Size:64 oz
Additionally, the overexpression of SIRT2 increases the deacetylation level of FoxO1 to inhibit autophagy in HK-2 cells treated with LPS and increases the production of pro-inflammatory factors, thereby aggravating CLP-induced SAKI (Yu et al., 2025)
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