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More recently, a quantitative CT-based algorithm that included CT density gradient and airway structure measurements has been shown to predict ECOPD more accurately than history of previous exacerbation and the BODE index 38 , although routine HRCT before discharge may neither be practical nor feasible

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Furthermore, NAD levels in the brain are essential for maintaining central nervous system (CNS) vascular integrity, due to NAD maintaining an energy supply that plays crucial roles in cell survival, such as having a protective factor in cerebral ischemia, since its disorder leads to energy depletion (, )