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An amount of 200 mg ion-exchange resins (TMD-8 hydrogen and hydroxide form, Sigma-Aldrich Chemie GmbH, Taufkirch, Germany) was added, mixed well and incubated for 30 min at room temperature

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Its mechanisms include: Actin polymerization — mobilizes cellular building blocks for tissue repair Cell migration — accelerates fibroblast and keratinocyte movement to injury sites Angiogenesis — promotes new blood vessel formation via VEGF upregulation Anti-inflammatory — reduces IL-1β and TNF-α at injury sites TB-500's smaller molecular size gives it excellent tissue distribution throughout the body