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This highly expressed Interferon-gamma (IFN-γ) stimulates STAT1 and xanthine dehydrogenase(XDH) transcription in a manner dependent on IRF1, wherein STAT1 and IRF1 get attracted to the promoter, further recruiting CREB binding protein (CBP) to spur XDH transcription

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Notably, the overall appearance of the high-dose group closely resembled that of the control group (Fig