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Notably, the tumor suppressor p53 binds directly to the peroxisome proliferator-activated receptor gamma coactivator 1-alpha ( PPARGC1A ) promoter, where it recruits histone deacetylases (HDACs) and other corepressor complexes to suppress transcription

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However, longitudinal studies are needed to determine if BBB disruption during acute infection predisposes to the development of long COVID-associated brain fog