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Rather than acting as a parallel or secondary layer of resistance, microenvironmental cues continuously interact with intracellular signaling, metabolic, and epigenetic programs within melanoma cells, potentially facilitating reversible survival states during treatment
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Pack:5-Week Treatment
The synthetically lethal effect was observed when deletion Dre2 and mitochondrial iron importers (Mrs3 and Mrs4) (Zhang et al., 2008)
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