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Both pigment types are derived from the common precursor dopaquinone, which is formed from the oxidation of L-tyrosine by the enzyme tyrosinase (4) ( Figure 1 )

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Furthermore, a recent 2024 study highlighted the critical role of CD8 T-cell dysfunction in both ME/CFS and Long COVID, noting that these immune cells produce markedly less necessary cytokines when exhausted by oxidative stress