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285 Screening of the bicyclic peptide library against the G12V mutant K-Ras protein identified a K-Ras inhibitor that blocked the Ras-Raf interaction with an IC 50 value of 3.4 μM, inhibited MEK and AKT phosphorylation, and induced apoptosis of lung cancer cells at low μM concentrations (compound 42 , Figure 19)
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an inhibitor of IGF-I action ( Figure 2 )
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