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Vitamin C is a cofactor for a family of metalloenzymes with pleotropic biosynthetic and gene regulatory roles ( Gulo knockout mice with melanoma and breast tumors following supplementation with low dose oral vitamin C (0.15 g/L, Figure 1 ) (Polireddy et al., 2017)

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N-acetylcysteine (NAC) is a synthetic derivative of the endogenous amino acid L-cysteine that is able to modulate glutamatergic neurotransmission and the excitatory/inhibitory ratio (26, 27)