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It is unclear how redoxins within the nucleus obtain their reducing power from cytosolic TrxR1 or Gsr, but most likely this will be by a dithiol-disulfide shuttle involving GSH-GSSG and perhaps the redoxins, themselves
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The results demonstrated that p53 protein expression was significantly suppressed by high doses of uric acid (12.5, 25 and 50 mg/dl) during prolonged stimulations (6-24 h)
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