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Over time, the liver can activate a secondary pathway (the microsomal ethanol-oxidizing system, involving the CYP2E1 enzyme) that increases alcohol clearance speed — but this comes at the cost of more oxidative stress on liver cells, which is part of why long-term heavy drinking damages the liver even as short-term “tolerance” seems to build

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The 2.0 mL dilution gives a clean 5 mg/mL (5,000 mcg/mL), so a 1,000 mcg dose reads as exactly 20 units (0.20 mL)