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Tesamorelin, an FDA-approved GHRH analog for HIV-associated lipodystrophy, raises IGF-1 levels by 50-100% in treated patients 8
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The most recent preclinical efficacy study, Babula, Bui, Stevenson, and colleagues, published in Diabetes, Obesity and Metabolism in 2024, confirmed that NNMT inhibition mitigates obesity-related metabolic dysfunction in preclinical models
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