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APOE4 increases risk, accounting for ~65% of AD cases (Mayeux et al., APOE2 protects against AD and APOE3 does not affect risk (Anonymous, APOE4 carriers are more likely than males to develop mild cognitive impairment between 55 and 70 years old (Neu et al., Despite the established relationship between APOE genotype and AD, it is not fully understood how APOE4 mediates risk

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