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doi: 10.1016/j.anifeedsci.2006.06.018

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If left unmonitored or untreated, approximately one-third of these chronically infected individuals will develop end-stage liver disease, such as cirrhosis or HBV-related HCC (HBV-HCC) 1,2,3,4 , which is associated with more than 600,000 deaths annually 5,6