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The MHRA (2022) recently issued guidance on the increased risk of vitamin B12 deficiency in people treated with metformin, highlighting increased risks with higher metformin doses, longer treatment duration and in patients with risk factors for B12 deficiency, including the following: Existing low B12 levels

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The researchers attributed the inverse correlation to the tumor-suppressive effects of the autophagy induced by spermidine, which can help manage defects that commonly lead to cancer (e.g., inflammation and genomic instability).10 11 12 Cardiovascular diseases In a 2013 study, researchers determined that spermidine supplementation could potentially reverse arterial aging, which is characterized by stiffening of the arteries and dysfunction of their cellular lining.13 If you have stiff arteries, your heart has to work harder to pump blood (as seen in hypertension), which in turn elevates your risk for heart disease and stroke,14 so it's imperative to keep them as elastic as possible