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Consistently, ADORA2b KO mice displayed marked reductions in glycolytic flux, ATP levels, and glutathione recycling, closely phenocopying the metabolic phenotype of stored RBC from high-caffeine human donors

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A recurrent feature in these organisms is the enhanced coupling between the molecular clock and key metabolic pathways, including insulin/IGF-1 signaling, glucose metabolism, and mTOR regulation, which are centrally involved in human aging and its associated pathologies, as well as in maintaining DNA integrity