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In our study using INS-1 cells, we demonstrated that ceramide induces β-cell apoptosis by promoting mitochondrial dysfunction, activating NF-κB, and upregulating TXNIP, an endogenous inhibitor of thioredoxin, which disrupts redox balance and reduces insulin gene expression

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GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems

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