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Some of the common pathways include the insulin pathway (McClure et al., 2011), the mitogen-activated protein kinase (MAPK) signaling pathway (Abnoos et al., 2013), the Notch signaling pathway (Alattia et al., 2011), folate metabolism (Affleck and Walker, 2008), fatty acid metabolism (Logan-Garbisch et al., 2015), the dopaminergic pathway (Bainton et al., 2000), and Wnt, TGFβ, Hedgehog, EGF, and cytokine pathways

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In particular, many such findings were related to neurological and neurodegenerative diseases associated with excess iron and detected using earlier versions of MRI signal intensity relaxation time techniques [128,129,130,131,135,136,137,138,139]