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Consequently, reduced activation of downstream signaling pathways, particularly the NF-κB pathway, downregulated cathepsin K and TRAP , and mitigated ROS-induced chondrocyte apoptosis by regulating apoptotic gene expression were recorded, which ultimately contributed to reduce subchondral bone remodeling and cartilage degeneration in OA patients
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Glutathione also helps combat oxidative stress, thus having a positive effect on the nervous, respiratory, digestive, and cardiovascular systems
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