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101 This allelic variant has been suggested to potentially influence the stability of the GSTP1-1/JNK complex and, subsequently, JNK activity, contingent upon the redox status of the cell

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Symptoms of glutathione synthetase deficiency may include: Seizures Hampered reaction to speech and physical stimuli Poor coordination Intellectual disability Vulnerability to bacterial infections Low glutathione levels are also associated with a large number of disorders, including some types of cancer and AIDS