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The majority of clinical trials investigating disease-modifying therapies have sought to halt or reverse the deposition of specific proteins in the brain and, while the first disease-modifying drug targeting protein deposition has been approved for AD (Cummings, 2023), two different phase II clinical trials of antibodies targeting α-synuclein in PD patients have not shown any effect on symptom relief (Kharel and Ojha, 2023)

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Therefore, strategic reduction of M1 macrophages or their cytokine expression could potentially alleviate the inflammatory response in HUA and its associated complications