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Additional patterns of change were observed for several other immune factors that were flagged for inclusion in the pathway analysis ( p -values between .05 and .15): pro-inflammatory factors interferon (IFN)-γ, leptin, and VEGF-A and anti-inflammatory cytokine IL-1RA all increased in the multinutrient responder group and decreased in the non-responder group, while levels of IL-6 decreased in both groups