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1i), suggesting an increased order within the system, likely due to the formation of a coordination complex between KDS12025, Hb, and H 2 O 2 (Supplementary Fig
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Furthermore, acidic pH or high-salt conditions cause release of PP-IX and disaggregation of the proteins, a process referred to as “deporphyrination.” This proteotoxic property of porphyrins is a major mechanism for tissue damage in porphyrias that involve accumulation of fluorescent porphyrin such as protoporphyrin-IX, uroporphyrinogen and coproporphyrinogen.(reviewed in [90]) In a recent study, Maitra et al., investigated the hypothesis that PP-IX-mediated protein aggregation is modulated by PP-IX speciation into selective supramolecular structures that lead to differential oxidizing potential and protein binding