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In summary, while research on phenolic acids in PD is still emerging, compounds like paeoniflorin and gallic acid exemplify how these polyphenols can intervene in PD pathogenesis by modulating neurotransmitter systems, enhancing protein clearance mechanisms, and protecting neurons from oxidative/inflammatory injury

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Similarly, primary cultures of embryonic rat-derived NSPCs respond to E2 increasing their proliferation ( GPER-1 has been found to be widely expressed in NSPCs (Zhang et al., 2019