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This finding is potentially significant for rotator cuff repairs, where the mechanical demands on the healed tissue are extreme — supporting the weight of the arm, allowing overhead reaching, and transmitting rotational forces

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When suffering from NDs, excessive extracellular glutamate will cause excitotoxicity, which will also competitively inhibit System Xc-, thus depleting GSH in neurons, this will reduce the function of GPX4, destroy the redox balance of our cells, lead to the accumulation of iron-dependent lipid peroxides, and finally promote the cell death, making cells very fragile and prone to ferroptosis (73, 74)