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Foundational evaluation of FOXO4-DRI in senescent cell apoptosis induction via FOXO4-p53 interaction disruption, with tissue homeostasis restoration in chemotoxicity and natural aging mouse models Investigation of FOXO4-DRI in senescent Leydig cell clearance and age-related testosterone secretion insufficiency in aged mouse models Assessment of FOXO4-DRI as a senolytic agent in in vitro expanded human chondrocyte research models for cartilage biology applications Investigation of FOXO4-DRI in endothelial cell senescence via the p53/BCL-2/Caspase-3 signaling pathway in vascular aging research models All data referenced on this page is derived from published preclinical animal and in vitro studies