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In addition, the accumulation of homocysteine promotes oxidative stress, and the trapped methyl group impairs the cell’s ability to transmethylate, resulting in DNA hypomethylation [97]

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This triple mechanism distinguishes it from dual-agonist peptides like tirzepatide (GLP-1/GIP) and single-agonist compounds like semaglutide (GLP-1 only), making it the most broadly acting incretin-class compound currently under clinical investigation