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The studies also had some shortcomings, as some only administered fluoxetine at the end of pregnancy and could not assess the effects of the drug throughout the entire pregnancy period, some did not explore the specific mechanisms of fluoxetine-induced fetal acidosis, hypocalcemia, and altered maternal estradiol metabolism, and some failed to assess the maternal and fetal health status over a long-term follow-up period

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Topical vitamin A/retinoids — as a skincare multitasker family, retinols are also helpful to treat hyperpigmentation as they inhibit tyrosinase and help exfoliate the topmost layer of the skin