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Some targets in epileptogenesis include the mammalian target of rapamycin (mTOR), P-glycoprotein (P-gp), and mutations in voltage-gated ion channels like hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and Kv7 channels (or M-channels), Na-K-2Cl cotransporter isoform 1 (NKCC1) [8, 12]