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20 , 21 Furthermore, this vitamin is an essential nutrient with markedly important functions in the skeletal muscle–gut–brain axis, such as maintenance of skeletal muscle and neurobehavioral parameters 22–25 and modulation of gut microbiota

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The canonical function of Gα i family G proteins is to bind directly to and inhibit adenylyl cyclase isoforms, thereby leading to a decreased cAMP concentration in cells