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Cognitively normal APOE ε4 carriers with high CSF ferritin have increased risk of cognitive decline compared to non-ε4 carriers [19], and in another cohort, the odds ratio for CSF ferritin in predicting AD diagnosis was higher in ε4 subjects [20]
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It has not received FDA approval for any indication, and no New Drug Application (NDA) has been submitted that would require the standard battery of in vitro CYP inhibition/induction assays and clinical DDI trials mandated by FDA guidance on drug interaction studies
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