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Indeed, high-dose oral gavage (200 mg/kg) and prolonged low-dose administration via drinking water exhibited a comparable significant protective effect against DSS-induced colitis, reflected by longer colon length, alleviated histopathological changes, less infiltration of IL-6-secreting macrophages, increased number of mucin-secreting goblet cells, higher expression level of ZO-1, occluding, Muc2 and decreased colonic expression of proinflammatory cytokines IL-1β, IL-6 and TNF-α at D7 post-DSS administration (Fig

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