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At the transcriptional level, TGF-β activates activating transcription factor 4 (ATF4) through both Smad3 and PI3K–Akt–mTORC1 pathways [108]

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However, contrary to this opinion, we believe that in the specific case of COVID-19 it is of paramount importance taking due account of the fact that PAC and its metabolites decrease GSH levels, also when given at relatively low doses in healthy volunteers (Stahl et al., 2015)