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IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons - PMC

Elevated ROS levels can trigger TRAF6 overexpression, and the activation of CD40-TRAF6 signaling, in turn, further enhances ROS generation 35,36,37,38

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These genes are involved in a wide variety of biological functions such as antioxidant defense, inflammation, immunity, and anti-apoptosis (69, 131)