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FDA Advisory No. 2019-398*** The Food and Drug Administration (FDA) advises the public from purchasing and consumption of the following unregistered food supplements: 1. UCORP Spirulina Troche Tablet 2. LUXCENT Luminous Caps

3 Manifestations of metabolic pathway features in the tumor microenvironment and medical imaging 3.1 Metabolism-immune interaction pathway and tumor immune microenvironment The lipid-rich, hypoxic metabolic ecology of ccRCC will systematically “transform” the metabolic state and function of immune cells in the TME, which is a key driver of immunotherapy drug resistance (Niu et al., 2025a)

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