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showed that pharmacologic impairment of mitochondrial function by respiratory chain inhibitors (metformin, rotenone or antimycin) (Figure 1B) also induced reductive glutamine metabolism in cells with functional mitochondria, evidence in support of a more general role for reductive glutamine metabolism in cancer cells
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Dose:5 mg
To date, potential therapies have been identified for cancers that are deficient in the switch/sucrose non-fermentable (SWI/SNF) complex, trimethylation of histone H3 lysine 36 (H3K36me3), CREB-binding protein (CBP), S -methyl-5′-thioadenosine phosphorylase (MTAP) and KDM6A
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