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C-terminal divergent segment between GhGPX4 and GhGPX12 triggers global secondary structure remodelling with concurrent increases in α-helix, β-sheet, and random coil, which might impact the molecular interactions, ultimately leading to difference of function ( Supplementary Figures 5 , 6 ) ( 3.5 Screening and validation of glutathione peroxidase interacting proteins Expression profiling and functional analysis of GhGPX indicated that GhGPX4 played a crucial role in ROS metabolism in the Jin A-CMS line

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