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Until detailed knowledge concerning FQ toxicity would be recognized, the following directions in supporting FQAD patients are proposed according to the known and probable mechanisms of FQ toxicity: Reduction of the oxidative stress: assuming that H 2 O 2 is not effectively removed from the cell after FQ treatment, subsequent consequences may occur such as opening Kv1.5 channels, Fenton reaction, peroxynitrite radical creation, opening PTP channels, decoupling mitochondrial potential, and, finally, breaking down OS barrier