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In NPCs from patients with IVDD, there is an upregulation of the mitochondrial fission protein DRP1 and a downregulation of the fusion protein mitofusin 2 (MFN2), resulting in a significant increase in the proportion of fragmented mitochondria ( Furthermore, the accumulation of succinate due to impaired citric acid cycle activity increases the ROS peak at Complex I through reverse electron transfer (RET), resulting in a reduction in mtDNA copy number and an elevated mutation rate of genes encoding Complexes I and IIII (Wang et al., 2024c)

Energy & Motivation

Unités:60 gélules

De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination

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