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In patients with metastatic colorectal cancer with induced arterial hypertension, 84.6% achieved a complete or partial response, when compared with 42.6% of patients who did not show this side effect and Kaplan–Meier analysis showed a statistically significant improvement in median progression-free survival for patients with induced arterial hypertension (15.1 versus 8.3 months, P = 0.04) [77]