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The primary routes for permeation across the BBB–include passive diffusion (lipid soluble solutes), ABC transporter efflux, carrier-mediated influx, and receptor-mediated transcytosis (Abbott et al., 2010)
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For influenza A, there are at least 18 hemagglutinin (HA) and 12 neuraminidase (NA) subtypes, with group 1 and group 2 species sharing only ~37% sequence homology for HA and NA proteins and only ~25% sequence homology with influenza B species (reviewed in ref
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