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Additionally, Aβ affects tau protein kinase 1 (TPK1), which, by over phosphorylating tau protein, inhibits PDH, thereby inhibiting mitochondrial reactions involving acetyl-CoA and citrate, reducing acetylcholine synthesis, and leading to memory and cognitive impairments (Ihara et al., 1986
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[DOI] [PubMed] [Google Scholar] 108.Xue C, Lan-Lan W, Bei C, Jie C, Wei-Hua F