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In AD models, Pitt and colleagues demonstrated that mature hippocampal neurons responded to pinitol (3-O-methyl DCI), glycan INS-2 and D-chiro-inositol (DCI) with increased phosphorylation of upstream insulin signaling components

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In addition to various integrins that the cell uses to engage the ECM, CD44 also interacts with ligands in the ECM, such as hyaluronan, collagen, fibronectin, and osteopontin